glutathione reductase inhibitor Derivative - an overview It favors its accumulation in the regions of high electron flux in cells where reactive species are generated. glutamate glutathione reductase Inhibition of

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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

This is a localized cellular dysfunction

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doi: 10.1016/j.mam.2008.05.005 16 StipanukMH