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11 However, this meta-analysis included only five articles analyzing the dose-dependency between the number of cigarettes smoked and CKD, and no significant relationship was found between CKD incidence and smoking fewer than 20 cigarettes per day

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The FDA must create clearer pathways through FDA Centers such as the Center for Drug Evaluation and Research or the Center for Devices and Radiological Health (CDER and CDRH) for products and interventions that are proven to help people quit and have been approved as treatments