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No vape is completely risk-free, but options that use USP-grade vegetable glycerin and propylene glycol, contain no diacetyl or vitamin E acetate, and have published third-party lab results are considered the least harmful

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The study doesn't definitively prove this is the case, "but it is very nice supporting data," Rigotti, who wasn't involved in the study, said by email.

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The specific concern is particularly acute for the growing market for novel tobacco and nicotine products particularly certain electronic nicotine delivery systems whose manufacturers may have less established regulatory compliance histories