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There is evidence that the [pouch] products deliver substantial levels of nicotine that are able to curb tobacco-related withdrawal symptoms, Hrywna says, but she adds that additional independent studies in humans are needed

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Through its review of the scientific literature, as well as the Agency's science-based, iterative research and development process (described in sections V and VI), FDA determined that having warning statements focused on less-known health consequences of smoking accompanied by photorealistic images can promote greater public understanding of the risks associated with cigarette smoking, especially given the unnoticed and invisible 1984 Surgeon General's warnings currently used in the United States (see section V.A)

Co-occurring mental health disorders that lead to self-medication with tobacco