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Reviews summarized in the paper described increased oxidative stress in e-cigarette users compared with nonsmokers, as well as inflammatory changes and altered methylation patterns associated with cancer-related pathways

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The precursors of ceramides (sphingomyelin, glucosylceramides) were also unaffected by long-term smoking although an increasing trend in the content of phospholipids (average increase of 58%) in smokers compared to non-smokers was observed

Plasma nicotine levels The results of plasma nicotine level measurements are shown in Fig