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A study on mtDNA content observed significantly increased mtDNA copy number in lung epithelial cells from smokers compared to non-smokers, and the increase was closely correlated to nuclear DNA methylation [34]

It was established in 1977

[1] As a result, Philip Morris's stock fell 26%, and the share value of other branded consumer product companies, including Coca-Cola and RJR Nabisco, fell as well

Curiously, however, data from the French cohort of never-smokers does not show this pattern in fact, Couraud reports, those data show no relationship between second-hand smoke exposure and any driver mutation

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