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Sources and full results Most relevant research papers on this topic DOI DOI DOI DOI DOI DOI DOI DOI DOI DOI

doi:10.1016/j.dsx.2021.102275 Menne J, Dumann E, Haller H, Schmidt BMW

Nonetheless, in a small crossover study of 26 human diabetic patients, 4 weeks of ebselen treatment did not alter plasma levels of oxidative stress markers, such as GSH/GSSG, isoprostanes, and nitrotyrosine, compared to placebo treatment [82]

Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1