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Previous studies have demonstrated that e-cigarette aerosol contains chemicals (acrolein, formaldehyde and benzene) 1 , cytotoxic flavor chemicals (diacetyl, cinnamaldehyde) 2,3 , metals 4,5 and free radicals 6 that can cause serious diseases

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Upon exposure to oxidative stress, the sequestration complex brakes down and the dissociated Nrf2 translocates into the nucleus, where it binds to cis-acting antioxidant response elements and promotes the transcription of a large number of cytoprotective genes (56, 57)

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