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When nicotine enters the body, it binds to neurotransmitter receptors in the brain called nicotinic acetylcholine receptors (nAChRs) that in turn bind to the neurotransmitter acetylcholine (Ach)

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How does smoking up your cancer risk

That is twice the rate found in the general population, and nearly 1.5 times the rate of death by other addiction-related causes