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Retatrutide adds glucagon receptor activation for enhanced metabolic effects beyond what dual agonism provides

Preclinical in vivo evidence: energy expenditure, substrate selection, and adiposity In chow-fed mice kept at thermoneutrality, repeated SLU-PP-332 administration increases energy expenditure, lowers RER (favoring fat over carbohydrate oxidation), and reduces adipocyte size, without changing food intake or spontaneous locomotor activity

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NRF2 activation contributes to a rise in ATP energy for mitochondria, in addition to enhanced use of oxygen, or citrate, and fat