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Widely used in all parts of the world as a stimulant, usually by smoking the plant or chewing it, in larger doses nicotine causes vomiting, diarrhoea, slow pulse, dizziness, collapse, and respiratory failure[ ]

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As far as dopamine is concerned, elevated brain dopamine concentrations also exert oxidative stress, due to the oxidative processes involved in dopamine metabolism: MAO produces H 2 O 2 and dihydroxyphenylacetic acid through a catalytic dopamine reaction (37)

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