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Acknowledgements The authors would like to thank Mark Tanner and Jonathan Howard for their invaluable help and expertise in the early stages of this study, and would also like to extend thanks to the Imanova Centre for Imaging Sciences for general support of the work

2004 The first commercial e-cigarette is introduced in China 2006 E-cigarettes are introduced to Europe first, then the United States 2008 In a study funded by Ruyan, a detailed quantitative analysis concludes that, overall the product tested was deemed a safe alternative to smoking. Beginning in 2009, regulatory battles begin on e-cigarettes

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Scotten is a board certified Pediatrician in Arizona