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An animal experimental study from Saudi Arabia showed that prenatal exposure to shisha smoke lowers the response to novel environments whereas passive exposure to the smoke of the local pipe (shisha) during pregnancy had no effects on the gestational period, number of pups, birth weight, and body weight growth [127]

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Incapsula incident ID: 641000730008402492-29843971140293200

Overall, cigarette and EC exposure may be considered possible immune-inflammatory modifiers in OA rather than only background lifestyle factors, although the OA-specific effects of EC exposure require further direct investigation

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