This 18th issue of the Scientific Update, issued in February 2024, discusses how science-based regulation can foster innovation and encourage adult smokers to switch to less harmful alternatives
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Psychotic disorders, and particularly schizophrenia, are serious illnesses which typically first manifest during the period of adolescence and emerging adulthood.1 The first-episode psychosis (FEP) is defined as a variable syndrome, lasting continuously for at least one week, characterized by the presence of positive symptoms, predominantly hallucinations and delusional ideas, and other accompanying symptoms, including negative, affective and cognitive symptoms.2 The prevalence of tobacco use in first-episode psychosis patients is higher than in the general population.3 On the one hand, it has been observed that the higher mortality after first-episode psychosis it is partially due to cardiovascular disease and a large percentage of the excess mortality as 70% of smoking related diseases.4,5 On the other hand, the fact that tobacco dependence poses a high financial burden also contributes to the social disadvantage and consequent decline of many of these patients with psychotic illnesses.6 Several theories have been proposed to explain why individuals with psychosis are more vulnerable to initiate and maintain tobacco use

Furthermore, as vapour products do not contain filters like cigarettes, the part-filter method for estimating MLE is inappropriate