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continued until disease progression or unacceptable toxicity

Investigator-initiated studies are small and not designed to be submitted to regulatory agencies like the FDA for approval

Third-party HPLC/MS verified with a certificate of analysis on every batch

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Patient disposition for active-controlled RCTs (PIONEER 2 to 4), placebo-controlled RCTs (PIONEER 1, 5, 8), the CVOT (PIONEER 6), and the population-specific safety studies (PIONEER 9, 10) are presented in Table 23, Table 24, Table 25, and Table 26, respectively

Self-directed microdosing usually has none of that