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Avoid exposure to direct sunlight and moisture

Visible improvement on a benign macule begins after the first complete renewal cycle, with significant fading typically appearing after three to six cycles depending on the depth and density of the pigmentation

Rosa Neto JC, Lira FS, Oyama LM, Zanchi NE, Yamashita AS, Batista Jr ML, et al

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Exposure to cadmium also potentially reduces cerebral blood flow (158) [particularly cortical blood flow (159)], as cadmium has a disruptive effect on angiogenesis (160)

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