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In a review of 136 NRT-related Cochrane Tobacco Addiction Group studies, substantial evidence supported NRT use in increasing the chances of successfully quitting smoking by 50 to 60% in comparison to placebo or a non-NRT control group

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9 Conversion of tobacco smoke compounds to reactive forms results in gene mutation, DNA damage, abnormal DNA methylation, formation of DNA adducts, pulmonary inflammation, oxidative stress, abnormal proliferation, abnormal differentiation, Epithelial-Mesenchymal Transition (EMT) and so on

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