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(B) Combination Therapy Highly dependent smokers, smokers who experience breakthrough cravings or those who have failed with single Nicotine Replacement Therapy (NRT) treatment, can use a flexible smoking cessation format, in combination with the patch for fast relief of cravings

had higher levels of biomarkers of exposure to nicotine and a cancer-causing toxicant -- the tobacco-specific nitrosamine NNK -- compared with those who used only cigarettes

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