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Nature (2008) 456:25963.10.1038/nature07416 38 DeuringJJFuhlerGMKonstantinovSRPeppelenboschMPKuipersEJde HaarCet alGenomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohns disease

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Second, research suggests that when nicotine artificially triggers a dopamine release, your brain starts making less of its own, relying on nicotine to keep you feeling good

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