Studies of other GLP-1 receptor agonists provide relevant context
Eur J Clin Nutr 70(4):532534
Mechanistically, P4HA1 enhances glycolytic activity in endothelial cells by down regulating fructose-1, 6-bisphosphatase 1 (FBP1), a negative regulator of glycolysis
Even moderate alcohol intake can substantially reduce the caloric deficit necessary for weight loss, potentially explaining poor treatment response in otherwise adherent patients
It affects everything from mental health to cardiovascular disease risk to hormone balance, and plays a role in how your body synthesizes melatonin for sleep, glutathione for antioxidant defence, and creatine for muscle performance
Ma X, Liu Z, Ilyas I, Little PJ, Kamato D, Sahebka A et al (2021) GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential