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A minimum lethal dose of nicotine in dogs is reported at 4 mg per pound body weight, but clinical signs have been seen at a dose of 0.4mg per pound body weight

[12] [13] Research found that the use of this imagery led to many smokers, including Indigenous peoples, having the misperception that the brand was owned or operated by a tribe/on tribal land and that it was more "natural" and thus healthier

eJournal of Indian Medicine

This can lead to prolonged exposure to toxic substances found in smokeless tobacco, increasing the chances of developing various health problems

Archived from the original on January 22, 2009.

Chemicals in tobacco smoke increase the chance of heart problems and cardiovascular diseases