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Clozapine is metabolized by CYP1A2 and CYP3A4 and partially also by CYP2C19

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Likewise, another study with a similar study population reported a higher risk of lung cancer incidence in current smokers 35

In short, it is advisable to denormalize the use of non-nicotine ECs in both adolescent and adult populations, to increase the risk perception of its use