Abbreviations AJ: Adherent junction AZI: Azithromycin BALF: Bronchoalveolar lavage fluid COPD: Chronic obstructive pulmonary disease CS: Cigarette smoke CSE: Cigarette smoke extract GCL: Glutamate cysteine ligase GS: Glutathione synthetase GST: Glutathione S-transferase HBECs: Human bronchial epithelial cells Keap1: Kelch-like ECH-associated protein-1 MSEA: Metabolite set enrichment analysis NC: Negative control Nrf2: Nuclear factor erythroid 2-related factor 2 PBECs: Primary bronchial epithelial cells PCA: Principal component analysis SD: Sprague Dawley shRNAs: Short-hairpin RNAs TBHQ: Tert-butylhydroquinone TEER: Transepithelial electronic resistance TJ: Tight junction TNF-: Tumor necrosis factor-alpha Vc: Vitamin C ZO-1: Zonula occludens-1 References Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W
Heavy smokers who consumed a pack or more daily typically have high tolerance levels
It was like Christmas and Easter is the only time you go in that room
Her actual delivery is also slower and more drawn-out (again, making sense for the character since Caroline Bingley was so dedicated to performing the role of the perfect upper class woman)
Talk with the person who smokes about the harms of secondhand smoke and the benefits of a smoke-free home
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