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Tobacco smoking is responsible for the deaths of at least six million people every year and, if current trends continue, the World Health Organisation predicts more than 1 billion tobacco-related deaths this century

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Furthermore, the advent of new and more sensitive chromatographic analytical techniques has allowed the Food and Drug Administration (FDA) to update the number of different substances released by the combustion of tobacco, bringing them to over 7 thousand 2 , some of which have irritant properties (e.g

The linear correlation between the two metabolites was determined using the Pearson correlation coefficient

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