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DA vapor exposure increased CD14 and IL1B gene expression, HA production and promoted mobilization of NHBECs Three of the most significantly upregulated GO pathways in response to DA exposure included Lipopolysaccharide (LPS) mediated signaling, Positive regulation of epithelial cell migration and Cellular response to mechanical stimulus

Clinically, in patients with severe COPD, continuous therapy of AZI combined with nebulized colistin dramatically prevented the exacerbations of COPD [35]

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