Vitamin E oil has been the leading culprit in the lung damage, though other chemicals and additives can't be ruled out, according to the CDC
Nature 408, 307310 (2000)
The hydrolytic cleavage of its 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole moiety generates M1, which undergoes further transformations involving hydroxylation and oxidation, mediated largely by CYP3A4 (Szumowski and Lynch, 2015
Alternatives and Harm Reduction For those looking to reduce tobacco-related harm, understanding actual alternatives matters
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Damage to a silver dollar-sized spot deep in the brain seems to wipe out the urge to smoke, a surprising discovery that may shed important new light on addiction