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Collectively, the radicals and oxidants generated can cause damage to proteins, lipids, and DNA, inactivate antiproteases, deplete antioxidants, and promote a proinflammatory environment by enhancing the phagocytotic respiratory burst and expression of proinflammatory mediator genes in the lung 97, 101

Similarly, a study by Durmus et al

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In addition, smoking and smokeless tobacco exposures increase carcinogenesis of the upper respiratory and digestive tracts (oral, oropharyngeal, hypopharyngeal, laryngeal, and oesophageal), bladder, pancreas, renal pelvis, liver, large bowel, and stomach [91]