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While OPLL may remain asymptomatic or manifest with nonspecific symptoms, even minor trauma can precipitate severe neurological deficits, including sensory and motor impairments, reflex abnormality, and urinary/fecal dysfunction

Activation of downstream effectors, including the mechanistic target of rapamycin complex 1 (mTORC1) and ribosomal protein S6 (S6), regulates protein synthesis, cell growth, and metabolism

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It is important to note that higher-dose semaglutide (2.4 mg, marketed as Wegovy) is licensed specifically for weight management in obesity and has separate eligibility criteria and dosing from the diabetes indication