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Metabolic profiling of dried blood spots from patients with HS identified significant features that suggest a glycolytic disturbance, including a decrease in glyceraldehyde-3-phosphate, a glycolytic intermediate, and 2,3-bisphosphoglycerate, which is produced via conversion of 1,3-bisphosphoglycerate, another metabolite of glycolysis, in the LueberingRapoport glycolytic shunt and is responsible for enhancing oxygen dissociation from hemoglobin (Hb) (4)

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Aging Cell 17 , e12834 (2018)

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Glutamate-treated rats had higher albumin levels in their brain compared to control rats [20] Other agents that may increase BBB permeability : Aspartate, taurine, ATP, endothelin-1, NO, MIP-2, TNF-a, MIP2, IL-h, bradykinin, 5HT, histamine, thrombin, UTP, UMP, quinolinic acid, platelet activating factor, and free radicals [2] How Do Researchers Detect a Leaky BBB

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