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FDA's tobacco director Mitch Zeller said the new effort is supported by research documenting how the warnings will educate the public about lesser-known smoking harms, such as bladder cancer

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However, the existing data on a general substitution effect at the population level are based on behavioral survey data, which is infrequent (e.g., annual) and limited by self-report

Effects of the specific alpha4beta2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice