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Side Effects and Tolerability: What to Expect Both medications share common side effects, primarily gastrointestinal symptoms like nausea, constipation, and reduced appetite during the initial weeks of therapy

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The repolarization effect of M1 MEVs works by converting M2 macrophages, which are typically associated with tumor progression and immune suppression, into M1-like macrophages that promote an anti-tumor immune response (198, 199)

Throughout this escalation, the principle remains the same

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