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Our data not only unveils a previously unknown pathway of ERMCS-localised GPCR signalling into mitochondria, potentially applicable to other GPCRs beyond the GLP-1R, but also opens the door to further roles of the GLP-1R in the regulation of mitochondrial lipid metabolism, a process tightly linked to changes in mitochondrial morphology governed by MICOS complex activity 10

Schimelpfening, Nancy

Safety and Side Effects at Lower GLP-1 Doses Lower doses generally produce fewer gastrointestinal side effects while still delivering weight loss benefits

This peak to trough optimization can be achieved through optimized drug steady rate trough concentration, which should be above the concentration threshold required to achieve the desired efficacy

After propensity score matching, both cohorts included 350,536 patients each

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