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Wnt/-catenin signaling drives epithelial senescence and fibroblast activation via -catenin-dependent transcriptional programs [73], while PI3K/AKT signaling, activated through PTEN loss or IGF1-mediated mechanisms [15,75], further promotes epithelial senescence and fibrotic progression
Eur J Pharmacol 443 : 113118
ISBN 9780385546539
As dubious as the claims of benefits from banning a particular flavor of tobacco may be, they don't venture quite so far into the land of magical thinking as another assertion in the letter
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