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At the same time, it also activates nicotinic acetylcholine receptors in the brain and appears to cause a release of both dopamine and endogenous opioids, which activate opioid pathways in the neural reward system, producing feelings of pleasure and contributing to its reinforcing effects

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(eds) New York: Plenum Press pp 4566 Hecht S

doi:10.1136/tc.2010.040170