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Smoking cigarettes or even routine exposure to secondhand smoke interferes with the normal functioning of your heart, blood, and vascular systems in ways that significantly increase your risk of having a heart attack or stroke
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Wen M, Yang Z, Wei Y, Huang H, Zheng R, Wang W, et al
These individual variations in nicotine tolerance are at least in part due to the pharmacogenetics of Cytochrome P450 2A6 (CYP2A6), the hepatic enzyme primarily responsible for nicotine metabolism [18]
Additionally, the authors note that PMIs premarket application did not adequately examine the health consequences of dual product use, consider potential youth attraction and use of the product, or evidence that consumers recognize the perceived addiction risk of the product
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