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Additional considerations have recently emerged over the off-label prescribing of medications for weight loss on whether the risk outweighs the benefits

2014 Oct;124(10):4204-11

A 1:1 blend of CJC-1295 No DAC (5mg) and Ipamorelin (5mg) designed to optimize growth hormone (GH) release, promoting muscle growth, fat loss, and enhanced tissue repair

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased