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This leads to the destruction of parietal cells, achlorhydria, and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption

Wiser et al., 2010

The UK government says adults need 1.5 micrograms (mcg) a day, the US National Institutes of Health advises 2.4mcg, and the European Food Safety Authority says 4mcg a day is adequate

When to contact your GP: Before starting any weight loss medication If you experience concerning side effects from current medications If you have not achieved meaningful weight loss (5%) after 12 weeks of treatment If you are considering combining medications or supplements If you have symptoms suggesting complications (chest pain, severe abdominal pain, persistent vomiting) Report any suspected side effects to the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)

mutants , which is likely an anti-plaque effect (597, 598)

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