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Although youth cigarette use is declining, e-cigarettes use by high school students has risen dramatically, with menthol and mint ranking as the second most popular flavors, after fruit

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And Juul, a major e-cigarette distributor, posted a statement saying, We strongly agree with the need for aggressive category-wide action on flavored products. The CDC is reviewing more than 450 cases of suspected vaping injuries in 33 states and has recorded six deaths none in Pennsylvania

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Fourthly, unobserved pleiotropy cannot be addressed in MR analysis