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Decreased CBF precedes the detectable changes of classical A and tau biomarkers, as well as brain atrophy, suggesting that reduced CBF could be a valuable biomarker in preclinical AD [138, 179]

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Integrated multi-omics approaches including transcriptomics, genomics, proteomics, metabolomics, and phenomics are transforming our understanding of resilience by revealing interactions among genes, proteins, and metabolites (Yang et al

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