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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

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selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]

doi: 10.1016/j.beem.2017.03.003 29 GaheteMDCordoba-ChaconJLinQBruningJCKahnCRCastanoJPet al

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