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"However, should the FDA become aware of an increase of youth using any other flavored products (both cartridge-based or otherwise), the agency will take additional steps to address youth use of those products if necessary." Since at least some adolescent vapers who like cartridge-based e-cigarettes will switch to menthol or tobacco when the flavors they currently prefer become harder to get, while others may switch to refillable vaporizers, those "additional steps" seem inevitable

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Cardiovascular toxicity of nicotine: implications for electronic cigarette use

Even their representatives (the Tobacco Manufacturers Association) accept that the consumption of illicit tobacco in the UK is falling