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Women, in particular, are more prone as estrogen, the predominant female hormone responsible for vessel wall integrity, can fluctuate during pregnancy and menopause [12]

Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)

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