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Each sample was run with the full MS method for general metabolites and with the parallel reaction monitoring (PRM) method for bromobimane alkylated metabolites

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Lopez-Chaves et al., Gold nanoparticles: distribution, bioaccumulation and toxicity

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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)