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Muscle oxygen uptake and energy turnover during dynamic exercise at different contraction frequencies in humans

This is due to an elevation in endorphins, which are the body's natural pain reduction and pleasure chemicals that are produced in the brain

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1 But, these neurotransmitters can also affect your sleep cycle and lead to a worse nights sleep overall

For CIRS patients, this mechanism raises an important practical question: could nicotine serve as a short-term adjunct or bridge therapy for supporting VIP pathways