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Am J Respir Crit Care Med 191:285291 Moretto N, Facchinetti F, Southworth T, Civelli M, Singh D, Patacchini R (2009) alpha, beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases

Key findings from current evidence: Pouches effectively reduce nicotine urges without inhalation Users who transition from smoking report high satisfaction No combustion means significantly lower exposure to harmful by-products Harm reduction potential is recognised among adult users leaving smoking That said, experts do flag important nuances

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finally, the parameters were presented in Table 1

After 10 years: Within 5-10 years, risk of having a stroke drops to the same as that of a non-smoker, Risk of developing cancers of the lungs, mouth, throat, esophagus, bladder, kidney and pancreas continues to drop