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These interactions contribute to significant alterations in liver biochemistry and histology

Patients with multiple high-risk variants often see better long-term outcomes with extended GLP-1 use, while those with fewer genetic risk factors may achieve durable results with temporary treatment plus lifestyle modification

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1 Asymptomatic autoimmune gastritis likely precedes gastric atrophy by 10 to 20 years, followed by the onset of iron-deficiency anemia that occurs as early as 20 years before vitamin B 12 deficiency pernicious anemia

Cochrane Database Syst Rev 2017;12:CD007963.ArticlePubMedPMC 72