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Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]
Based on data derived from our previous study [8], inclusion of 16 participants was calculated to provide at least 90% power (at = 0.01 to allow for subgroup comparisons) to detect a 20% difference in glucose iAUC 0120min between metformin treatments and the control