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"Nicotine poisoning occurs when nicotine begins to exhibit more dire toxic effects on an individual." The Centers for Disease Control and Prevention (CDC) warns that 50 to 60 milligrams of nicotine is a deadly dose for an adult who weighs about 150 pounds

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These toxicity endpoints can, for instance, be assessed in normal human bronchial epithelial cell cultures using High Content Screening [47, 48]

In Italy, the Ministry of Health declared NicStic was not a drug and green-lighted its sale without any restrictions, according to NicStic

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