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Acyl-CoA synthase long-chain family member 4 (ACLS4) is a fatty acid activating an enzyme that catalyzes the esterification of long-chain PUFAs such as arachidonic (AA) and adre-noyl (AdA) to form PE, which is an integral component in the GPX4-dependent ferroptosis pathway [33, 34]

Clinical trials have demonstrated its effectiveness in treating chronic viral infections like Hepatitis B and C, as well as its role as an adjunct in cancer immunotherapy by boosting the immune systems ability to fight cancer cells

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The agency gave its nod to 37 new molecular entities in 2022