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That said, the possible negative effects of smoking still outweigh the potential side effects in most cases, according to recent Pros and cons of non-nicotine prescription medications Treatment may also include the use of non-nicotine prescription medications, such as bupropion (Zyban, Wellbutrin SR, Wellbutrin XL, Aplenzin, and Forfivo XL) or varenicline (Chantix, Tyrvaya, Champix)